In comedy, there likely isn’t a more Odd Couple-type pairing than Ray Romano and David Spade. Romano, who, when he pushes the boundaries of how adult he wants to take his comedy, goes all the way to PG. Spade, on the other hand, can be, uh, snippy; a joke about Eddie Murphy on his segment “Hollywood Minute” on Saturday Night Live caused a rift between Murphy and the show for years.

When one thinks of who might be on the bill with Romano, one thinks of his co-headlining gigs with fellow family-friendly comic Kevin James in Vegas. And when one considers Spade, memories of his party boy gigs with fellow Saturday Night Live alumni Rob Schneider and Adam Sandler brings smiles to one’s face.

Of course, they do have plenty of things in common in their careers—Romano starred in the über-successful Everybody Loves Raymond, in the critically acclaimed adult drama Men of a Certain Age and recently, in a recurring role in Parenthood. Spade, after his Saturday Night Live years, had huge successes in TV shows Just Shoot Me! and Rules of Engagement, and plenty of movies—he recently costarred with Sandler in the Netflix action comedy The Do-Over.

For audiences, their differences mean these two opposites might just create the best kind of comedy.

The Mirage, 10 p.m. Feb. 24-25, starting at $79.99 plus tax and fee, 16+ with adult. 702.792.7777