David Spade’s humor is just as dry as the desert surrounding Las Vegas. The Saturday Night Live alum’s roster of hits include the sitcoms Rules of Engagement and Just Shoot Me plus movies Black Sheep and Joe Dirt. Now he’s a regular at The Venetian, bringing his stand-up routine with just the right amount of Vegas references in it.

You’ve performed at the big rooms in Las Vegas—Wynn, The Mirage and now The Venetian. You know this town better than any tourist ... Do you like to gamble in Vegas? What’s your game of choice?

I started off as a gambler and slowly got away from it. I have to rely on my movie credits to get into clubs and restaurants. I’ve never had a free room. … I’m not very good at gambling. One night I was with Marilyn Manson at the Hard Rock and after my show he wanted to gamble. They cleared away an entire blackjack table for us. I think they thought we’d be betting $5,000 a hand. We were putting down $20 or $50 a round. After five minutes, they let the people come back. We thought we were the two biggest ballers.

Is this one of your offices because you’re here working (or) can you come here and have a fun time?

It’s very rare that I’m going out while I’m working a show. Everyone has a camera. The days of autographs are over. I sign one autograph to every 1,000 photos. I’m pretty good about pictures. Ninety-nine percent of people are very cool. Sometimes they come sit with me at dinner. You can’t say anything. No one ever thinks they were wrong, but if you say something, they think you’re an asshole. I get that, and I get that the selfie is a new thing. Usually they’re taking a picture before I even know it. They’re hugging me and the camera goes off ... I’m finding I don’t look great with a camera eight inches from my face.

You have fans from SNL, Joe Dirt, Rules of Engagement and comedy specials. How has your audience changed?

I sort of have a wide range of fans, which is nice. People know me from the Emperor’s New Groove or Rules of Engagement, then they see a new thing. Some people only saw me on Just Shoot Me or Tommy Boy. I’m lucky to have a few that worked. I’ve found my cockiness dissipates when I find out they don’t like me. I was reading some nasty tweets on Jimmy Kimmel (Live). The one they wouldn’t let me read was, “I wish you died instead of Chris Farley.” I get that about once a week. The one they let me read said, “F*** David Spade.”

How much Vegas material are you using in your act?

I do I try to include a lot. I did my Comedy Central special and intentionally pulled a lot of my Vegas material from it so people would see something different. I talk about a lot of the hotels. That’s usually good for me. It’s a lot of fun.

The Venetian, 8 p.m. July 5, starting at $65.75 plus tax and fee. 702.414.9000